ANKRD25

Protein-coding gene in the species Homo sapiens
KANK2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4HBD

Identifiers
AliasesKANK2, ANKRD25, MXRA3, SIP, PPKWH, KN motif and ankyrin repeat domains 2, NPHS16
External IDsOMIM: 614610; MGI: 2384568; HomoloGene: 9163; GeneCards: KANK2; OMA:KANK2 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for KANK2
Genomic location for KANK2
Band19p13.2Start11,164,267 bp[1]
End11,197,791 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for KANK2
Genomic location for KANK2
Band9|9 A3Start21,678,080 bp[2]
End21,710,040 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • saphenous vein

  • gastric mucosa

  • urethra

  • body of uterus

  • right coronary artery

  • popliteal artery

  • tibial arteries

  • canal of the cervix

  • sural nerve

  • left uterine tube
Top expressed in
  • ascending aorta

  • interventricular septum

  • aortic valve

  • belly cord

  • ciliary body

  • sciatic nerve

  • left lung lobe

  • gastrula

  • iris

  • internal carotid artery
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • mitochondrion
Biological process
  • negative regulation of G1/S transition of mitotic cell cycle
  • negative regulation of programmed cell death
  • negative regulation of intracellular estrogen receptor signaling pathway
  • negative regulation of transcription by RNA polymerase II
  • negative regulation of vitamin D receptor signaling pathway
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • negative regulation of cell population proliferation
  • apoptotic process
  • kidney epithelium development
  • glomerular visceral epithelial cell migration
  • regulation of Rho protein signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25959

235041

Ensembl

ENSG00000197256

ENSMUSG00000032194

UniProt

Q63ZY3

Q8BX02

RefSeq (mRNA)

NM_015493
NM_001136191
NM_001329451

NM_145611

RefSeq (protein)
NP_001129663
NP_001316380
NP_056308
NP_001366477
NP_001366478

NP_001366479
NP_001366480
NP_001366481
NP_001366482
NP_001366483
NP_001366484
NP_001366485
NP_001366486
NP_001366487
NP_001366488
NP_001366489
NP_001366490
NP_001366491
NP_001366492

NP_663586

Location (UCSC)Chr 19: 11.16 – 11.2 MbChr 9: 21.68 – 21.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

KN motif and ankyrin repeat domain-containing protein 2 is a protein that in humans is encoded by the KANK2 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197256 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032194 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  6. ^ Zhu Y, Kakinuma N, Wang Y, Kiyama R (Jan 2008). "Kank proteins: a new family of ankyrin-repeat domain-containing proteins". Biochim Biophys Acta. 1780 (2): 128–33. doi:10.1016/j.bbagen.2007.09.017. PMID 17996375.
  7. ^ "Entrez Gene: ANKRD25 ankyrin repeat domain 25".

External links

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Zhang Y, Zhang H, Liang J, et al. (2007). "SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm". EMBO J. 26 (11): 2645–57. doi:10.1038/sj.emboj.7601710. PMC 1888672. PMID 17476305.


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