BIRC6

Protein-coding gene in the species Homo sapiens
BIRC6
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3CEG

Identifiers
AliasesBIRC6, APOLLON, BRUCE, baculoviral IAP repeat containing 6
External IDsOMIM: 605638; MGI: 1276108; HomoloGene: 7248; GeneCards: BIRC6; OMA:BIRC6 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for BIRC6
Genomic location for BIRC6
Band2p22.3Start32,357,023 bp[1]
End32,618,878 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for BIRC6
Genomic location for BIRC6
Band17|17 E2Start74,835,290 bp[2]
End75,010,351 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic epithelial cell

  • Achilles tendon

  • pancreatic ductal cell

  • mucosa of ileum

  • tibialis anterior muscle

  • bone marrow cells

  • epithelium of colon

  • corpus callosum

  • skin of arm

  • mucosa of sigmoid colon
Top expressed in
  • tail of embryo

  • internal carotid artery

  • external carotid artery

  • genital tubercle

  • thymus

  • seminal vesicula

  • ventricular zone

  • cumulus cell

  • submandibular gland

  • ascending aorta
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • peptidase inhibitor activity
  • cysteine-type endopeptidase inhibitor activity
  • ubiquitin-protein transferase activity
  • protein binding
  • ubiquitin conjugating enzyme activity
  • transferase activity
Cellular component
  • cytoplasm
  • endosome
  • spindle pole
  • membrane
  • microtubule organizing center
  • trans-Golgi network
  • cytoskeleton
  • Golgi apparatus
  • intracellular membrane-bounded organelle
  • midbody
  • Flemming body
  • nucleus
Biological process
  • negative regulation of peptidase activity
  • spongiotrophoblast layer development
  • regulation of cytokinesis
  • placenta development
  • labyrinthine layer development
  • negative regulation of extrinsic apoptotic signaling pathway
  • negative regulation of apoptotic process
  • cell division
  • protein phosphorylation
  • regulation of cell population proliferation
  • protein ubiquitination
  • positive regulation of cell population proliferation
  • cell cycle
  • apoptotic process
  • negative regulation of endopeptidase activity
  • ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57448

12211

Ensembl

ENSG00000115760

ENSMUSG00000024073

UniProt

Q9NR09

O88738

RefSeq (mRNA)

NM_016252
NM_001378125

NM_007566

RefSeq (protein)

NP_057336
NP_001365054

NP_031592
NP_001389698

Location (UCSC)Chr 2: 32.36 – 32.62 MbChr 17: 74.84 – 75.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene.[5][6]

Function

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.[6]

Interactions

BIRC6 has been shown to interact with KIF23.[7]

Diseases

BIRC6 is implicated in leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and other cancers[8] (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology[9]).

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115760 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024073 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chen Z, Naito M, Hori S, Mashima T, Yamori T, Tsuruo T (Dec 1999). "A human IAP-family gene, apollon, expressed in human brain cancer cells". Biochem Biophys Res Commun. 264 (3): 847–54. doi:10.1006/bbrc.1999.1585. PMID 10544019.
  6. ^ a b "Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon)".
  7. ^ Pohl C, Jentsch S (Mar 2008). "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE". Cell. 132 (5): 832–45. doi:10.1016/j.cell.2008.01.012. PMID 18329369. S2CID 12192141.
  8. ^ "BIRC6 (Baculoviral IAP repeat-containing 6)". atlasgeneticsoncology.org.
  9. ^ "Atlas of Genetics and Cytogenetics in Oncology and Haematology". atlasgeneticsoncology.org.

External links

  • Human BIRC6 genome location and BIRC6 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Baculoviral IAP repeat-containing protein 6

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
  • Qiu XB, Markant SL, Yuan J, Goldberg AL (2005). "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis". EMBO J. 23 (4): 800–10. doi:10.1038/sj.emboj.7600075. PMC 380992. PMID 14765125.
  • Bartke T, Pohl C, Pyrowolakis G, Jentsch S (2005). "Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase". Mol. Cell. 14 (6): 801–11. doi:10.1016/j.molcel.2004.05.018. PMID 15200957.
  • Hao Y, Sekine K, Kawabata A, Nakamura H, Ishioka T, Ohata H, Katayama R, Hashimoto C, Zhang X, Noda T, Tsuruo T, Naito M (2004). "Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function". Nat. Cell Biol. 6 (9): 849–60. doi:10.1038/ncb1159. PMID 15300255. S2CID 22850781.
  • Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.
  • Qiu XB, Goldberg AL (2005). "The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9". J. Biol. Chem. 280 (1): 174–82. doi:10.1074/jbc.M411430200. PMID 15507451.
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Chaperones/
protein folding
Heat shock proteins/
Chaperonins
Other
Protein targetingUbiquitin
(ubiquitylation)Ubiquitin-like proteins
(UBL)
SUMO protein
(SUMOylation)
  • E1 SUMO-activating enzyme
  • E2 SUMO-conjugating enzyme
Other


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