Basaloid follicular hamartoma
Medical condition
| Basaloid follicular hamartoma | |
|---|---|
 | |
| Basaloid hamartoma | |
| Specialty | Dermatology |
Basaloid follicular hamartoma is a cutaneous condition characterized as distinctive benign adnexal tumor that has several described variants.[1]: 675 It manifest as small tan or brown coloured papules in the trunk, pubic area, face, scalp, and axilla.
Basaloid follicular hamartoma is associated with a variety of disorders and is caused by mutation in the PTCH gene. The diagnosis is made based of histopathological examination.
Signs and symptoms
Basaloid follicular hamartoma manifests as multiple 1- to 2mm tan-to-brown-colored papules located on the pubic area, trunk, axilla, scalp, and face.[2]
Causes
Basaloid follicular hamartoma can be hereditary or acquired.[3]
Associated conditions include cystic fibrosis, systemic lupus erythematosus, myasthenia gravis, hypohidrosis, hypotrichosis, palmar pitting, and alopecia.[2]
Basaloid follicular hamartoma is caused by a mutation in the chromosome 9q23 patch (PTCH) gene, which is also the gene responsible for nevoid basal cell carcinoma syndrome.[4]
Diagnosis
The diagnosis of basaloid follicular hamartoma lesions requires a histopathological investigation.[2] Histopathological features include basaloid epithelial cells in the papillary dermis form multifocal islands and branching cords, some of which are attached to the epidermis and dilated hair follicles.[5]
Treatment
Various interventions, including photodynamic therapy, carbon dioxide laser, and surgery, have been suggested.[5]
See also
- Hamartoma
- Cutaneous condition
- List of cutaneous conditions
References
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ^ a b c Segars, Kelly; Cooper, Hassie; Hogan, Daniel J.; Miller, Richard; Heaphy, Michael; Spencer, James (2024-03-14). "Basaloid Follicular Hamartoma: A Case Report and a Novel Cosmetic Treatment". The Journal of Clinical and Aesthetic Dermatology. 11 (3). Matrix Medical Communications. PMID 29607000. Retrieved 2024-03-31.
- ^ Boccaletti, Valeria; Accorsi, Patrizia; Pinelli, Lorenzo; Ungari, Marco; Giordano, Lucio; Neri, Iria; De Panfilis, Giuseppe (2010-11-09). "Congenital Systematized Basaloid Follicular Hamartoma with Microphthalmia and Hemimegalencephaly". Pediatric Dermatology. 28 (5). Wiley: 555–560. doi:10.1111/j.1525-1470.2010.01225.x. ISSN 0736-8046.
- ^ Gumaste, Priyanka; Ortiz, Arisa E.; Patel, Amit; Baron, Jonathan; Harris, Ronald; Barr, Ronald (2015). "Generalized Basaloid Follicular Hamartoma Syndrome". The American Journal of Dermatopathology. 37 (3). Ovid Technologies (Wolters Kluwer Health): e37–e40. doi:10.1097/dad.0000000000000085. ISSN 0193-1091.
- ^ a b Edelman, Solange; Torres Huamani, Adriana Natalia; Centeno, María Del Valle; Cervini, Andrea Bettina (2022). "Basaloid follicular hamartoma associated with follicular mucinosis and inflammation". Anais Brasileiros de Dermatologia. 97 (1). Elsevier BV: 45–48. doi:10.1016/j.abd.2020.10.012. ISSN 0365-0596. PMC 8799845.
Further reading
- Mills, Omie; Thomas, L. Brannon (2010). "Basaloid follicular hamartoma". Archives of Pathology & Laboratory Medicine. 134 (8): 1215–1219. doi:10.5858/2008-0620-RS.1. ISSN 1543-2165. PMID 20670146. Retrieved 2024-03-31.
- Chikeka, Ijeuru; Chang, Li-Wei; Collins, Mary-Katherine; Pugliano, Melissa; Ho, Jonhan; House, Nancy; Kazlouskaya, Viktoryia (2022). "Basaloid Follicular Hamartoma: An Additional Criterion of Nevoid Basal Cell Carcinoma Syndrome". The American Journal of Dermatopathology. 44 (1): 66–69. doi:10.1097/DAD.0000000000001987. ISSN 0193-1091.
External links
- DermNet
- Pathology Outlines
