Dwarfin sma |
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Identifiers |
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Organism | Caenorhabditis elegans |
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Symbol | daf-8 |
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Entrez | 187612 |
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RefSeq (mRNA) | NM_059920.3 |
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RefSeq (Prot) | NP_492321.1 |
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UniProt | Q21733 |
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Other data |
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Chromosome | I: 8.58 - 8.59 Mb |
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Search for |
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Structures | Swiss-model |
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Domains | InterPro |
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The DAF-8 nematode gene encoding a R-SMAD protein of TGF-beta signaling pathway, which was originally found in model organism Caenorhabditis elegans.[1] When the TGF-β ligand daf-7 binds to the TGF-β receptors daf-1/daf-4 on the surface of nematode cell, daf-8 will be phosphorylated and forms a heterodimer with daf-14, then enter to the nucleus to inhibit transcription regulated by daf-3/daf-5.[2]
References
- ^ Li FF, Gasser RB, Liu F, Shan JN, Di WD, He L, et al. (April 2020). "Identification and characterization of an R-Smad homologue (Hco-DAF-8) from Haemonchus contortus". Parasites & Vectors. 13 (1): 164. doi:10.1186/s13071-020-04034-0. PMC 7119156. PMID 32245505.
- ^ Gumienny TL, Savage-Dunn C (July 2013). "TGF-β signaling in C. elegans". WormBook: 1–34. doi:10.1895/wormbook.1.22.2. PMC 5081272. PMID 23908056.
Dauer Formation Abnormal protein | |
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Downstream Of Daf protein | - Dod-3
- Dod-6
- Dod-13
- Dod-17
- Dod-18
- Dod-19
- Dod-20
- Dod-21
- Dod-22
- Dod-23
- Dod-24
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Daf-12-interacting protein | |
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