Monolysocardiolipin

Chemical structure of MLCL backbone

Monolysocardiolipin (MLCL) is a phospholipid with three fatty acid chains located in the inner membrane of mitochondria.

MLCL is normally present as part of the metabolic cycle of mitochondrial lipids, such as cardiolipin.[1] It is remodeled by the enzymes monolysocardiolipin acyltransferase, lysocardiolipin acyltransferase, and tafazzin, which transfer a fourth fatty acid chain onto the phospholipid.[2]

References

  1. ^ Ma BJ, Taylor WA, Dolinsky VW, Hatch GM (1999). "Acylation of monolysocardiolipin in rat heart". J Lipid Res. 40 (10): 1837–45. doi:10.1016/S0022-2275(20)34900-2. PMID 10508203.
  2. ^ Taylor, W. A.; Hatch, G. M. (2009). "Identification of the Human Mitochondrial Linoleoyl-coenzyme A Monolysocardiolipin Acyltransferase (MLCL AT-1)". Journal of Biological Chemistry. 284 (44): 30360–30371. doi:10.1074/jbc.M109.048322. ISSN 0021-9258. PMC 2781591. PMID 19737925.
  • v
  • t
  • e
Lipids: phospholipids
Glycerol backbone
(Glycerophospholipids/
Phosphoglycerides)
Phosphatidyl-:
  • -ethanolamine/cephalin (PE)
  • -choline/lecithin (PC)
  • -serine (PS)
  • -glycerol (PG)
  • -inositol (PI)
    • glyco- (GPI)
Phosphoinositides:
Ether lipids:
Sphingosine backboneMetabolites


Stub icon

This biology article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e