RAI14

Protein-coding gene in humans
RAI14
Identifiers
AliasesRAI14, NORPEG, RAI13, retinoic acid induced 14
External IDsOMIM: 606586; MGI: 1922896; HomoloGene: 9199; GeneCards: RAI14; OMA:RAI14 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for RAI14
Genomic location for RAI14
Band5p13.2Start34,656,328 bp[1]
End34,832,612 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for RAI14
Genomic location for RAI14
Band15|15 A1Start10,569,055 bp[2]
End10,714,710 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • visceral pleura

  • ventricular zone

  • smooth muscle tissue

  • placenta

  • decidua

  • glomerulus

  • amniotic fluid

  • metanephric glomerulus

  • myometrium
Top expressed in
  • renal corpuscle

  • lumbar spinal ganglion

  • ciliary body

  • left lung lobe

  • iris

  • hair follicle

  • endothelial cell of lymphatic vessel

  • ureter

  • maxillary prominence

  • sciatic nerve
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cell cortex
  • cytoskeleton
  • nucleus
  • fibrillar center
  • cytoplasm
  • cytosol
  • cell junction
Biological process
  • spermatogenesis
  • cell differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26064

75646

Ensembl

ENSG00000039560

ENSMUSG00000022246

UniProt

Q9P0K7

Q9EP71

RefSeq (mRNA)
NM_001145520
NM_001145521
NM_001145522
NM_001145523
NM_001145525

NM_015577

NM_001166408
NM_030690
NM_001356534

RefSeq (protein)
NP_001138992
NP_001138993
NP_001138994
NP_001138995
NP_001138997

NP_056392

NP_001159880
NP_109615
NP_001343463

Location (UCSC)Chr 5: 34.66 – 34.83 MbChr 15: 10.57 – 10.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ankycorbin is a protein that in humans is encoded by the RAI14 gene.[5][6] Ankycorbin has been associated with the cortical actin cytoskeleton structures in terminal web, cell-cell adhesion sites as well as stress fibres.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000039560 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022246 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kutty RK, Kutty G, Samuel W, Duncan T, Bridges CC, El-Sherbeeny A, Nagineni CN, Smith SB, Wiggert B (May 2001). "Molecular characterization and developmental expression of NORPEG, a novel gene induced by retinoic acid". J Biol Chem. 276 (4): 2831–40. doi:10.1074/jbc.M007421200. PMID 11042181.
  6. ^ "Entrez Gene: RAI14 retinoic acid induced 14".
  7. ^ Peng YF, Mandai K, Sakisaka T, Okabe N, Yamamoto Y, Yokoyama S, Mizoguchi A, Shiozaki H, Monden M, Takai Y (December 2000). "Ankycorbin: a novel actin cytoskeleton-associated protein". Genes Cells. 5 (12): 1001–8. doi:10.1046/j.1365-2443.2000.00381.x. PMID 11168586. S2CID 19149724.

Further reading

  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Yuan W, Zheng Y, Huo R, Lu L, Huang XY, Yin LL, Li JM, Zhou ZM, Sha JH (September 2005). "Expression of a novel alternative transcript of the novel retinal pigment epithelial cell gene NORPEG in human testes". Asian J. Androl. 7 (3): 277–88. doi:10.1111/j.1745-7262.2005.00040.x. PMID 16110356.
  • Kutty RK, Chen S, Samuel W, Vijayasarathy C, Duncan T, Tsai JY, Fariss RN, Carper D, Jaworski C, Wiggert B (July 2006). "Cell density-dependent nuclear/cytoplasmic localization of NORPEG (RAI14) protein". Biochem. Biophys. Res. Commun. 345 (4): 1333–41. doi:10.1016/j.bbrc.2006.04.184. PMID 16729964.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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