SLA2

Protein-coding gene in the species Homo sapiens
SLA2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4M4Z

Identifiers
AliasesSLA2, C20orf156, MARS, SLAP-2, SLAP2, Src-like-adaptor 2, Src like adaptor 2
External IDsOMIM: 606577; MGI: 1925049; HomoloGene: 49989; GeneCards: SLA2; OMA:SLA2 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SLA2
Genomic location for SLA2
Band20q11.23Start36,612,318 bp[1]
End36,646,196 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SLA2
Genomic location for SLA2
Band2|2 H1Start156,714,377 bp[2]
End156,729,112 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • granulocyte

  • monocyte

  • blood

  • testicle

  • lymph node

  • spleen

  • appendix

  • oocyte

  • bone marrow cells
Top expressed in
  • thymus

  • zygote

  • primary oocyte

  • secondary oocyte

  • granulocyte

  • embryo

  • blood

  • embryo

  • pharynx

  • morula
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • protein N-terminus binding
  • non-membrane spanning protein tyrosine kinase activity
  • signaling receptor binding
  • 1-phosphatidylinositol-3-kinase regulator activity
Cellular component
  • cytoplasm
  • late endosome
  • plasma membrane
  • endosome membrane
  • membrane
  • cytoplasmic vesicle
  • nucleoplasm
  • Golgi apparatus
  • intracellular membrane-bounded organelle
  • extrinsic component of cytoplasmic side of plasma membrane
  • phosphatidylinositol 3-kinase complex
Biological process
  • negative regulation of calcium-mediated signaling
  • negative regulation of B cell activation
  • intracellular receptor signaling pathway
  • negative regulation of transcription by RNA polymerase II
  • T cell activation
  • B cell mediated immunity
  • regulation of immune response
  • antigen receptor-mediated signaling pathway
  • positive regulation of signal transduction
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • cell migration
  • cell differentiation
  • peptidyl-tyrosine autophosphorylation
  • regulation of cell population proliferation
  • innate immune response
  • regulation of signal transduction
  • regulation of phosphatidylinositol 3-kinase activity
  • negative regulation of insulin receptor signaling pathway
  • phosphatidylinositol phosphate biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84174

77799

Ensembl

ENSG00000101082

ENSMUSG00000027636

UniProt

Q9H6Q3

Q8R4L0

RefSeq (mRNA)

NM_032214
NM_175077

NM_029983
NM_001356495

RefSeq (protein)

NP_115590
NP_778252

NP_084259
NP_001343424

Location (UCSC)Chr 20: 36.61 – 36.65 MbChr 2: 156.71 – 156.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.[5][6]

Function

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.[6]

Interactions

SLA2 has been shown to interact with Cbl gene.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101082 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027636 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J (Nov 2001). "Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling". J Exp Med. 194 (9): 1263–76. CiteSeerX 10.1.1.283.1429. doi:10.1084/jem.194.9.1263. PMC 2195979. PMID 11696592.
  6. ^ a b "Entrez Gene: SLA2 Src-like-adaptor 2".
  7. ^ Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M (May 2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219.

Further reading

  • Loreto MP, McGlade CJ (2003). "Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v". Oncogene. 22 (2): 266–73. doi:10.1038/sj.onc.1206114. PMID 12527895.
  • Loreto MP, Berry DM, McGlade CJ (2002). "Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling". Mol. Cell. Biol. 22 (12): 4241–55. doi:10.1128/MCB.22.12.4241-4255.2002. PMC 133880. PMID 12024036.
  • Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M (2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219.


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