Thiopurine
![](http://upload.wikimedia.org/wikipedia/commons/thumb/0/07/Tioguanine.svg/220px-Tioguanine.svg.png)
![](http://upload.wikimedia.org/wikipedia/commons/thumb/4/42/Mercaptopurine.svg/220px-Mercaptopurine.svg.png)
![](http://upload.wikimedia.org/wikipedia/commons/thumb/1/13/Azatiopryna.svg/220px-Azatiopryna.svg.png)
The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis), and organ transplant recipients.
Metabolism is catalyzed by S-methyltransferase and nudix hydrolase 15 (NUDT15).[1]
Litigation over patents covering diagnostic kits to monitor the dosing of these drugs led to a US Supreme Court case, Mayo Collaborative Services v. Prometheus Laboratories, Inc. that dramatically changed the nature of patent law in the United States.[2][3]
See also
- 6-Mercaptopurine (6-MP)
- 6-Thioguanine (6-TG)
- Azathioprine (AZA)
References
- ^ Sahasranaman S, Howard D, Roy S (August 2008). "Clinical pharmacology and pharmacogenetics of thiopurines". Eur. J. Clin. Pharmacol. 64 (8): 753–67. doi:10.1007/s00228-008-0478-6. PMID 18506437.
- ^ Supreme Court Decision. Mayo Collaborative Services v. Prometheus Laboratories, Inc., No. 10-1150, Slip Op. at 16. Decision
- ^ Gene Quinn, Killing Industry: The Supreme Court Blows Mayo v. Prometheus IP Watchdog (March 20, 2012).
External links
- http://www.pharmgkb.org/do/serve?objId=PA2040
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(M phase)
Block microtubule assembly | |
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Block microtubule disassembly |
inhibitor
DNA precursors/ antimetabolites (S phase) |
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Topoisomerase inhibitors (S phase) |
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Crosslinking of DNA (CCNS) |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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