ZFYVE20

Protein-coding gene in the species Homo sapiens
RBSN
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1YZM, 1Z0J, 1Z0K

Identifiers
AliasesRBSN, Rabenosyn-5, ZFYVE20, rabenosyn, RAB effector
External IDsOMIM: 609511; MGI: 1925537; HomoloGene: 41477; GeneCards: RBSN; OMA:RBSN - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for RBSN
Genomic location for RBSN
Band3p25.1Start15,070,073 bp[1]
End15,099,163 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for RBSN
Genomic location for RBSN
Band6|6 D1Start92,163,693 bp[2]
End92,191,906 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • myocardium of left ventricle

  • cardiac muscle tissue of right atrium

  • skin of arm

  • tibialis anterior muscle

  • cerebellar vermis

  • Brodmann area 23

  • Brodmann area 46

  • middle temporal gyrus

  • internal globus pallidus
Top expressed in
  • otic vesicle

  • Rostral migratory stream

  • supraoptic nucleus

  • hand

  • otolith organ

  • utricle

  • lumbar subsegment of spinal cord

  • medullary collecting duct

  • nucleus of stria terminalis

  • ascending aorta
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • zinc ion binding
  • metal ion binding
  • protein binding
  • nucleic acid binding
Cellular component
  • endosome
  • early endosome membrane
  • intracellular membrane-bounded organelle
  • membrane
  • cytoplasmic side of endosome membrane
  • plasma membrane
  • endosome membrane
  • extracellular exosome
  • cytosol
Biological process
  • endosomal vesicle fusion
  • endocytosis
  • vacuole inheritance
  • Golgi to endosome transport
  • blood coagulation
  • endosomal transport
  • protein transport
  • regulation of Golgi organization
  • Golgi to lysosome transport
  • early endosome to Golgi transport
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64145

78287

Ensembl

ENSG00000131381

ENSMUSG00000014550

UniProt

Q9H1K0

Q80Y56

RefSeq (mRNA)

NM_001302378
NM_022340

NM_030081

RefSeq (protein)

NP_001289307
NP_071735

NP_084357

Location (UCSC)Chr 3: 15.07 – 15.1 MbChr 6: 92.16 – 92.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rabenosyn-5 is a protein that in humans is encoded by the ZFYVE20 gene.[5][6]


Interactions

ZFYVE20 has been shown to interact with RAB5A.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131381 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014550 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M (Nov 2000). "Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain". J Cell Biol. 151 (3): 601–12. doi:10.1083/jcb.151.3.601. PMC 2185588. PMID 11062261.
  6. ^ "Entrez Gene: ZFYVE20 zinc finger, FYVE domain containing 20".

Further reading

  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Eathiraj S, Pan X, Ritacco C, Lambright DG (2005). "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5". Nature. 436 (7049): 415–9. Bibcode:2005Natur.436..415E. doi:10.1038/nature03798. PMC 1360218. PMID 16034420.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Naslavsky N, Boehm M, Backlund PS, Caplan S (2005). "Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane". Mol. Biol. Cell. 15 (5): 2410–22. doi:10.1091/mbc.E03-10-0733. PMC 404033. PMID 15020713.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • de Renzis S, Sönnichsen B, Zerial M (2002). "Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes". Nat. Cell Biol. 4 (2): 124–33. doi:10.1038/ncb744. PMID 11788822. S2CID 6596498.
  • v
  • t
  • e
  • 1yzm: Structure of Rabenosyn (458-503), Rab4 binding domain
    1yzm: Structure of Rabenosyn (458-503), Rab4 binding domain
  • 1z0j: Structure of GTP-Bound Rab22Q64L GTPase in complex with the minimal Rab binding domain of Rabenosyn-5
    1z0j: Structure of GTP-Bound Rab22Q64L GTPase in complex with the minimal Rab binding domain of Rabenosyn-5
  • 1z0k: Structure of GTP-Bound Rab4Q67L GTPase in complex with the central Rab binding domain of Rabenosyn-5
    1z0k: Structure of GTP-Bound Rab4Q67L GTPase in complex with the central Rab binding domain of Rabenosyn-5


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